Wang, Y.; Hoye, T. R. Org. Lett. 2018, 20, 88–91.
Reported here are studies that have established novel features of the hexadehydro-Diels–Alder reaction of substrates containing tethered trapping moieties. Products having new structural motifs can be created. (i) Medium-sized fused rings can be produced by varying the length of the tether. (ii) The tether can emanate from an atom within the linker unit that joins the 1,3-diyne and diynophile. (iii) The importance of the rate of trapping by the benzynophile is established.