No-D NMR (No-Deuterium Proton NMR) Spectroscopy:  A Simple Yet Powerful Method for Analyzing Reaction and Reagent Solutions

The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.

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