Older Publications (1972–2011)

2011

A strategy for control of random copolymerization of lactide and glycolide: Application to synthesis of PEG-b-PLGA block polymers having narrow dispersity. Qian, H.; Wohl A. R.; Crow, J. T.; Macosko, C. W.; Hoye, T. R. Macromolecules 2011, 44, 7132-7140. (doi:10.1021/ma201169z) 

Allylmalonate as an activator subunit for initiation of relay ring-closing metathesis (RRCM) reactions. Hoye, T. R.; Jeon, J.; Tennakoon, M. A. Angew. Chem. Int. Ed. 2011, 50, 2141-2143. (doi:10.1002/anie.201005044

Synthesis and olfactory activity of unnatural, sulfated 5b-bile acid derivatives in the sea lamprey (Petromyzon marinus). Burns, A. C.; Sorensen, P. W.; Hoye, T. R. Steroids 2011, 76, 291-300. (doi:10.1016/j.steroids.2010.11.010

Access to functionalized steroid side chains via modified Julia olefination. Izgu, E. C.; Burns, A. C.; Hoye, T. R. Org. Lett. 2011, 13, 703-705.  (doi:10.1021/ol102936z)

Receptor screening technologies in the evaluation of Amazonian ethnomedicines with potential applications to cognitive deficits. McKenna, D. J.; Ruiz, J. M.; Hoye, T. R.; Roth, B. L.; Shoemaker, A. T. J. Ethnopharm. 2011134, 475-492. (doi:10.1016/j.jep.2010.12.037

2010

Total synthesis of (–)-callipeltoside A. Hoye, T. R.; Danielson, M. E.; May, A. E.; Zhou, H. J. Org. Chem. 2010, 75, 7052-7060 (Featured Article). 

A useful modification of the Evans magnesium halide catalyzed anti-aldol reaction: Application to enolizable aldehydes. May, A. E.; Connell, N. T.; Dahlmann, H. A.; Hoye, T. R. Synlett 2010, 13, 1984-1986. 

Total synthesis of peloruside A through kinetic lactonization and relay ring-closing metathesis cyclization reactions. Hoye, T. R.; Jeon, J.; Kopel, L. C.; Ryba, T. D.; Tennakoon, M. A.; Wang, Y. Angew. Chem. Int. Ed. 2010, 49, 6151-6155. Highlighted in Synfacts 2010, 6(12), 1330–1331 (doi:10.1005/s-0033-1258875 and 10.1005/s-0033-1258876). 

Room temperature acylketene formation: 1,3-Dioxin-4-ones via silver(i) activation of phenylthioacetoacetate in the presence of ketones. May, A. E.; Hoye, T. R. J. Org. Chem. 2010, 75, 6054-6056. 

Metathesis involving a relay and applications in natural product synthesis. Hoye, T. R.; Jeon, J. in Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts; Cossy, J., Arseniyadis, S., Meyer, C. Ed.; Wiley-VCH: Berlin, 2010,  pp 261–285. 

Long-range shielding effects in the 1H NMR spectra of Mosher-like ester derivatives. Hoye, T. R.; Erickson, S. E.; Erickson-Birkedahl, S. L.; Hale, C. R. H.; Izgu, E. C.; Mayer, M. J.; Notz, P. K.; Renner, M. K. Org. Lett. 2010, 12, 1768-1771.  

Synthesis of stable block-copolymer-protected NaYF4:Yb3+, Er3+ up-converting phosphor nanoparticles. Budijono, S. J.; Shan, J.-N.; Yao, N.; Miura, Y.; Hoye, T. R.; Austin, R. H.; Ju, Y.-G.; Prud'homme, R. K. Chem. Materials 2010, 22, 311–318. 

Dynamic kinetic resolution during a vinylogous Payne rearrangement: A concise synthesis of the polar pharmacophoric subunit of (+)-scyphostatin. Hoye, T. R.; Jeffrey, C. S.; Nelson, D. P. Org. Lett. 2010, 12, 52–55.  (doi:10.1021/ol902459z)  

2009

Controlled polymerization of a cyclic diene prepared from the ring-closing metathesis of a naturally occurring monoterpene. Kobayashi, S.; Lu, C.; Hoye, T. R.; Hillmyer, M. A. J. Am. Chem. Soc. 2009, 131, 7960-7961. (doi:10.1021/ja9027567)  

The evolution of chemistry through synthesis (and of synthesis in chemistry). Hoye, T. R.; Sizova, E. in Chemical Evolution II; ACS Symposium Series; Friedrich, J., Seidel, R., Zaikowski, L., Ed.; American Chemical Society: Washington, DC, 2009, 1025, pp 181-203. 

Maleimide functionalized poly(e-caprolactone)-block-poly(ethylene glycol) (PCL-PEG-MAL): Synthesis, nanoparticle formation, and thiol conjugation. Ji, S.; Zhu, Z.; Hoye, T. R.; Macosko, C. W. Macromol. Chem. Phys. 2009, 210, 823-831.  

Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. Efange, A. M. N.; Brun, R.; Wittlin, S.; Connolly, J. D.; Hoye, T. R.; McAkam, T.; Makolo, F. L.; Mbah, J. A.; Nelson, D. P.; Nyongbela, K. D.; Wirmum, C. K. J. Nat. Prod. 2009, 72, 280-283. 

2008

Dual macrolactonization/pyran-hemiketal formation via acylketenes: applications to the synthesis of (-)-callipeltoside A and a lyngbyaloside B model system. Hoye, T. R.; Danielson, M. E.; May, A. E.; Zhao, H. Angew. Chem. Int. Ed. 2008, 47, 9743-9746. 

Diamino telechelic polybutadienes for solventless styrene-butadiene-styrene (SBS) triblock copolymer formation. Ji, S.; Hoye, T. R.; Macosko, C. W. Polymer 2008, 49, 5307-5313. 

Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. strain PCC 7120. Agger, S. A.; Lopez-Gallego, F.; Hoye, T. R.; Schmidt-Dannert, C. J. Bacteriol. 2008, 190, 6084-6096.  

Preparation of poly(ethylene glycol) protected nanoparticles with variable bioconjugate ligand density. Gindy, M. E.; Ji, S.; Hoye, T. R.; Panagiotopoulos, A. Z.; Prud'homme, R. K. Biomacromolecules 2008, 9, 2705-2711. 

New nimbolinin and meliacarpin derivatives from Melia azedarach. Ayyad, S. N.; Hoye, T. H.; Sreerama, L.; Dawidar, A. M.; Alarif, W. M.; Abdel-Mogib, M. Rev, Latinoamer. Quim. 2008, 36, 7-15.  

A continuous catalytic system for biodiesel production. McNeff, C. V.; McNeff, L. C.; Yan, B.; Nowlan, D. T.; Rasmussen, M.; Gyberg, A. E.; Krohn, B. J.; Fedie, R. L.; Hoye, T. R. App. Cat. A.: Gen. 2008, 343, 39-48.

Decarboxylative isomerization of N-acyl-2-oxazolidinones to 2-oxazolines. May, A. E.; Willoughby, P. H.; Hoye, T. R. J. Org. Chem. 2008, 73, 3292–3294.  

A thermal decarbonylation of penam b-lactams. Wiitala, T. R.; Tian, Z.; Cramer, C. J.; Hoye, T. R. J. Org. Chem. 2008, 73, 3024–3031.  

2007

A critical review of the discovery and application of a migratory pheromone in an invasive fish, the sea lamprey Petromyzon marinus L.. Sorensen, P. W.; Hoye, T. R. J. Fish Biol. 2007, 71(Suppl. D), 100–114.          

Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons. Hoye, T. R.; Jeffrey, C. S.; Shao, F. Nature Protocols 2007, 2, 2451–2458. (doi:10.1038/nprot.2007.354)

Formation of block copolymer-protected nanoparticles via reactive impingement mixing. Zhu, Z.; Anacker, J. L.; Ji, S.; Hoye, T. R.; Macosko, C. W.; Prud’homme, R. K. Langmuir, 2007, 23, 10499–10504.

Details of the structure determination of the sulfated steroids PSDS and PADS–new components of the sea lamprey (Petromyzon marinus) migratory pheromone. Hoye, T. R.; Dvornikovs, V.; Fine, J. M.; Anderson, K. R.; Jeffrey, C. S.; Muddiman, D. C.; Shao, F.; Sorensen, P. W.; Wang, J. J. Org. Chem. 2007, 72, 7544–7550.

Comparison of various density functional methods for distinguishing stereoisomers based on computed 1H or 13C NMR chemical shifts using diastereomeric penam b-lactams as a test set. Wiitala, K. W.; Cramer, C. J.; Hoye, T. R. Magn. Reson. Chem. 2007, 45, 819–829.

Influence of stereochemistry on 1H and 13C chemical shifts in six isomeric methylcyclohexanols: Utility of DFT protocols for distinguishing stereoisomers. Wiitala, K. W.; Al-Rashid, Z. F.; Dvornikovs, V.; Hoye, T. R.; Cramer, C. J. J. Phys. Org. Chem. 2007, 20, 345–354.

Synthesis of maleimide functionalized poly(e-caprolactone)-b-poly(ethylene glycol) for nanoparticle formation. Ji, S.; Hoye, T. R.; Macosko, C. W. PMSE Preprints 2007, 96, 871-872.

2006

Trimethyl phosphonoacetate. Hoye, T. R.; Sizova, E. e-EROS Encyclopedia of Reagents for Organic Synthesis, First Update 2006, http://www.mrw.interscience.wiley.com/eros/articles/rt282/abstract-fs.html.

Topomimetics of amphipathic b-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins. Chen. X.; Dings, R. P. M.; Nesmelova, I.; Debbert, S.; Haseman, J. R.; Maxwell, J.; Hoye, T. R.; Mayo, K. H. J. Med. Chem. 2006, 49, 7754-7765.  PMC4242098

Functional block copolymer nanoparticles for targeted drug delivery and imaging. Gindy, Marian E.; Prud'homme, R. K.; Ji, S.; Hoye, T. R.; Macosko, C. W. PMSE Preprints 2006, 95, 989-990.

Silylative Dieckmann-like cyclizations of ester-imides (and diesters). Hoye, T. R.; Dvornikovs, V.; Sizova, E. Org. Lett 2006, 8, 5191-5194.

Sequencing of three-component olefin metatheses: Total synthesis of either (+)-gigantecin or (+)-14-deoxy-9-oxygigantecin. Hoye, T. R.; Eklov, B. M.; Jeon, J.; Khoroosi, M. Org. Lett. 2006, 8, 3383-3386. Highlighted in Synfacts 2007, 3(1), 9–9 (doi:10.1055/s-2006-955655).

Design of nonpeptidic topomimetics of antiangiogenic proteins with antitumor activities. Dings, R. P. M.; Chen, X.; Hellebrekers, D. M. E. I.; van Eijk, L. I.; Zhang, Y.; Hoye, T. R.; Griffioen, A. W.; Mayo, K. H. J. Natl. Cancer Inst. 2006, 98, 932-936.             

Performance comparison: ZirChrom®-chiral to silica CSPs. Henry, R.; Yan, B.; McNeff, C.; Hoye, T. LC-GC North America, 2006, 24 (June Supplement), 27.

Rules for in situ reactive formation and assembly of block copolymer drug nanoparticles. Anacker, J. L.; Prud’homme, R. K.; Macosko, C. W.; Hoye, T. R.; Saad, W. PMSE Preprints 2006, 94, 84.

Hybrid density functional methods empirically optimized for the computation of 13C and 1H chemical shifts in chloroform solution. Wiitala, K. W.; Hoye, T. R.; Cramer, C. J. J. Chem. Theory Comput. 2006, 2, 1085-1092.

In situ generation and nucleophilic capture of 1,n-dial equivalents from 1,n-dioates (a,w-diesters). Hoye, T. R.; Kopel, L. C.; Ryba, T. D. Synthesis 2006, 1572-1574.

Empowerment through ‘mini-microscale’ reactions: The epoxidation of 1 mg of geraniol. Hoye, T. R.; Jeffrey, C. S. J. Chem. Educ. 2006, 83, 919-920.

Charge storage model for hysteretic negative-differential resistance in metal-molecule-metal junctions. Kiehl, R. A.; Le, J. D.; Candra, P.; Hoye, R. C.; Hoye, T. R. Appl. Phys. Lett. 2006, 88, 172102/1-172102/3.       

Comparative Diels-Alder reactivities within a family of valence bond isomers: A biomimetic total synthesis of (±)-UCS1025A. Hoye, T. R.; Dvornikovs, V. J. Am. Chem. Soc. 2006, 128, 2550-2551. Highlighted in Synfacts 2006, 2(8), 761–761 (doi:10.1055/s-2006-941925).

2005

Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey. Sorensen, P. W.; Fine, J. M.; Dvornikovs, V.; Jeffrey, C. S.; Shao, F.; Wang, J.; Vrieze, L. A.; Anderson, K. R.; Hoye, T. R. Nature Chemical Biology 2005, 1, 324-328. (link)

Reactions at polymer–polymer interfaces for blend compatibilization. Macosko, C. W.; Jeon, H. K.; Hoye, T. R. Prog. Poly. Sci. 2005, 30, 939-947.

Divergent kinetic control of classical vs. ozonolytic lactonization: Mechanism-based diastereoselection. Hoye, T. R.; Ryba, T. D. J. Am. Chem. Soc. 2005, 127, 8256-8257. (doi:10.1021/ja051604b)

Reaction titration: A convenient method for titering reactive hydride agents (Red-Al, LiAlH4, DIBALH, L-Selectride, NaH, and KH) by No-D NMR spectroscopy. Hoye, T. R.; Aspaas, A. W.; Eklov, B. M.; Ryba, T. D. Org. Lett. 2005, 7, 2205-2208.

Primary amine (-NH2) quantification in polymers: Functionality by 19F NMR spectroscopy. Ji, S.; Macosko, C. W.; Hoye, T. R. Macromolecules 2005, 38, 4679-4686.

Alkyne haloallylation [with Pd(II)] as a core strategy for macrocycle synthesis: A total synthesis of (-) -haterumalide NA/(–)-oocydin A. Hoye, T. R.; Wang, J. J. Am. Chem. Soc. 2005, 127, 6950-6951. Highlighted in Synfacts 2005, 1(2), 195–195 (doi:10.1055/s-2005-916053).

No-D NMR study of the pathway for n-BuLi oxidation of 1,5-cyclooctadiene to dilithium cyclooctatetraene dianion [Li2COT2-]. Hoye, T. R.; Kabrhel, J. E.; Hoye, R. C. Org. Lett. 2005, 7, 275-277.

A novel chemical route to stable, regenerable zirconia-based chiral stationary phases for HPLC. Henry, R. A.; McNeff, C. B.; Yan, B.; Hoye, T. T. American Laboratory 2005, 37, 22-24.

2004

Relay ring closing metathesis (RRCM): A strategy for directing metal movement throughout olefin metathesis sequences. Hoye, T. R.; Jeffrey, C. S.; Tennakoon, M. A.; Wang, J.; Zhao, H. J. Am. Chem. Soc. 2004, 126, 10210-10211. (doi:10.1021/ja046385t)

Controlled synthesis of high molecular weight telechelic polybutadienes by ring opening metathesis polymerization. Ji, S.; Hoye, T. R.; Macosko, C. W. Macromolecules 2004, 37, 5485-5489.

Coupling reactions of end- vs. mid-functional polymers. Jeon, J. H.; Macosko, C. W.; Moon, B.; Hoye, T. R.; Yin, Z. Macromolecules 2004, 37, 2563-2571.

No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions. Hoye, T. R.; Eklov, B. M.; Voloshin, M. Org. Lett. 2004, 6, 2567-2570.

Synthesis and reactive blending of amine and anhydride end-functional polyolefins. Jones, T. D.; Macosko, C. W.; Moon, B.; Hoye, T. R. Polymer 2004, 45, 4189-4201.

No-D NMR (no deuterium proton NMR) spectroscopy: A simple yet powerful method for analyzing reaction and reagent solutions. Hoye, T. R.; Eklov, B. M.; Ryba, T. D.; Voloshin, M.; Yao, L. J. Org. Lett. 2004, 6, 953-956. (doi:10.1021/ja046385t)

2003

Reactions at polymer-polymer interfaces for blend compatibilization. Jeon, H. K.; Moon, B.; Hoye, T. R.; Macosko, C. W. Annu. Tech. Conf. - Soc. Plast. Eng. 2003, 61, 3784-3788.

Negative differential resistance in a bilayer molecular junction. Le, J. D.; He, Y.; Hoye, T. R.; Mead, C. C.; Kiehl, R. A. App. Phys. Lett. 2003, 83, 5518-5520.

Cytotoxic metabolites, new plakortide, bicyclic lactone and cyclic peroxides from the marine sponge Plakortis. Hoye, T. R.; Ayyad, Seif-Eldin N.; Abo-Elkarm, M.; Hamann, M. T. Mansoura Science Bulletin, A: Chemistry 2003, 30, 149-156.

Design of a partial peptide mimetic of anginex with antiangiogenic and anticancer activity. Mayo, K. H.; Dings, R. P. M.; Flader, C.; Nesmelova, I.; Hargittai, B.; van der Schaft, D. W. J.; van Eijk, L. I.; Walek, D.; Haseman, J.; Hoye, T. R.; Griffioen, A. W. J. Biol. Chem. 2003, 278, 45746-45752.

Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: A total synthesis of (-)-dactylolide [and zampanolide]. Hoye, T. R.; Hu, M. J. Am. Chem. Soc. 2003, 125, 9576-9577.

Cytotoxic hydroazulene diterpenes from the brown alga Cystoseira myrica. Ayyad, S. N.; Abdel-Halim, O. B.; Shier, W. T.; Hoye, T. R. Zeitschrift für Naturforschung C 2003, 58, 33-38.

2002

Synthesis and application of fluorescently labeled phthalic anhydride (PA) functionalized polymers by ATRP. Moon, B.; Hoye, T. R.; Macosko, C. W. Polymer 2002, 43, 5501-5509.

Toward computing relative configurations: 16-epi-Latrunculin B, a new stereoisomer of the actin polymerization inhibitor, latrunculin B. Hoye, T. R.; Ayyad, S. N.; Eklov, B. M.; Hashish, N. E.; Shier, W. T.; El Sayed, K. A.; Hamann, M. T. J. Am. Chem. Soc. 2002, 124, 7405-7410.

Reactivity of common functional groups with urethane: Models for reactive compatibilization of thermoplastic polyurethane blends. Lu, Q. W.; Hoye, T. R.; Macosko, C. W. Journal of Polymer Science: Part A: Polymer Chemistry 2002, 40, 2310-2328.

A method for easily determining coupling constant (J) values: An addendum to "A practical guide to first-order multiplet analysis in 1H NMR spectroscopy." Hoye, T. R.; Zhao, H. J. Org. Chem. 2002, 67, 4014-4016. (doi:10.1021/jo001139v)

2001

Synthesis of end- and mid-phthalic anhydride functional polymers by atom transfer radical polymerization. Moon, B.; Hoye, T. R.; Macosko, C. W. Macromolecules 2001, 34, 7941-7951.

A useful modification of the Kraus procedure for preparation of w-bromo-1-alkenes by HMPA-promoted elimination of HBr from 1,w-dibromoalkanes. Hoye, T. R.; Van Veldhuizen, J. J.; Vos, T. J.; Zhao, P. Synth. Comm. 2001, 31, 1367-1371.

Synthesis and X-ray crystallography of chiral tropocoronands. Chenier, P. J.; Halfen. J. A.; Raguse, T. L.; Rich, A. E.; Splan, K. E.; Yoshioka, K.; Hoye, T. R. Synth. Comm. 2001, 31, 487-503.

2000

Anionic synthesis and detection of fluorescence-labeled polymers with a terminal anhydride group. Moon, B.; Hoye, T. R.; Macosko, C. W. J. Polym. Sci., Part A. Polymer Chemistry 2000, 38, 2177-2185.

Total Synthesis of (-)-cylindrocyclophane A via a double Horner-Emmons macrocyclic dimerization event. Hoye, T. R.; Humpal, P. E.; Moon, B. J. Am. Chem. Soc. 2000, 122, 4982-4983.

Synthesis (and alternative proof of configuration) of the scyphostatin C(1')-C(20') trienoyl fragment. Hoye, T. R.; Tennakoon, M. A. Org. Lett. 2000, 2, 1481-1483.

An NMR method for determination of configuration of b-substituted carboxylic acids. Hoye, T. R.; Hamad, A. S.; Koltun, D. O.; Tennakoon, M. Tetrahedron Lett. 2000, 41, 2289-2293.

N-Methylputrescine oxidation during cocaine biosynthesis: Study of prochiral methylene hydrogen discrimination using the remote isotope method. Hoye, T. R.; Bjorklund, J. A.; Koltun, D. O.; Renner, M. K. Org. Lett. 2000, 2, 3-5.

1999

Some allylic substituent effects in ring closing metathesis reactions: Allylic alcohol activation. Hoye, T. R.; Zhao, H. Org. Lett. 1999, 1, 1123-1125.

Total synthesis of michellamines A-C, korupensamines A-D, and ancistrobrevine B. Hoye, T. R.; Chen, M.; Hoang, B.; Mi, L.; Priest. O. P. J. Org. Chem. 1999, 64, 7184-7201.

An enyne metathesis/(4 + 2)-dimerization route to (±)-differolide. Hoye, T. R.; Donaldson, S. M.; Vos, T. J. Org. Lett. 1999, 1, 277-279.

Synthesis of a C(1)-C(14) fragment of callipeltoside A. Hoye, T. R.; Zhao, H. Org. Lett. 1999, 1, 169-171.

Silicon tethered ring-closing metathesis reactions for self- and cross-coupling of alkenols. Hoye, T. R.; Promo, M. Tetrahedron Lett. 1999, 40, 1429-1432.

1998

A general, practical, and versatile strategy for accessing w-functional 1,2-diols of high enantiomeric excess. Hoye, T. R.; Mayer, M. J.; Vos, T. J.; Ye, Z. J. Org. Chem. 1998, 63, 8554-8557.

Otteliones A and B: Potently cytotoxic 4-methylene-2-cyclohexenones from Ottelia alismoides. Ayyad, S-E. N.; Judd, A. S.; Shier, W. T.; Hoye, T. R. J. Org. Chem 1998, 63, 8102-8106.

Synthesis of conformationally mobile bicyclic tetrahydro-1,2-oxazines by isomerization of isoxazolidinylmethyl tosylates. Goodwin, T. E.; Cousins, D. M.; Debenham, S. D.; Green, J. L.; Guyer, M. L.; Jacobs, E. G.; Hoye, T. R.; Koltun, D. O.; Vyvyan, J. R. J. Org. Chem. 1998, 63, 4485-4488.

An NMR strategy for determination of configuration of remote stereogenic centers: 3-Methylcarboxylic acids. Hoye, T. R.; Koltun, D. O. J. Am. Chem. Soc. 1998, 120, 4638-4643.

Development of synergistic NMR and molecular mechanics strategies for determining natural product stereochemistry. Hoye, T. R.; Ayyad, S-E. N.; Judd, A. S.; Koltun, D. O.; Renner, M. K. Pure Appl. Chem. 1998, 70, 2134-2134.

Amine-terminal polystyrenes: A new strategy for synthesis and new methods for determination of functionality. Cernohous, J. J.; Macosko, C. W.; Hoye, T. R., Macromolecules 1998, 31, 3759-3763.

An efficient (one-pot) synthesis of a new class of cyclophanes. Hoye, T. R.; Cernohous, J. J.; Pfister, K. Tetrahedron Lett. 1998, 39, 1857-1860.

Synthesis of azulenone skeletons by reaction of 2-phenyl-2-acylketenes [RCO(Ph)C=C=O] with alkynyl ethers: Mechanistic aspects and further transformations. Brown, D. G.; Hoye, T. R.; Brisbois, R. G. J. Org. Chem. 1998, 63, 1630-1636.

1997

A convenient synthesis of 1-bromo-4,5-dimethoxy-7-methylnaphthalene, a naphthol derivative useful for construction of naphthylisoquinoline alkaloids. Hoye, T. R.; Mi, L. J. Org. Chem. 1997, 62, 8586-8588.

A Synthesis of chiral tropocoronands. Chenier, P. J.; Judd, A. S.; Raguse, T. L.; Hoye, T. R. Tetrahedron Lett. 1997, 38, 7341-7344.

Anionic synthesis of polymers mono-functionalized with a terminal anhydride group. Cernohous, J. J.; Macosko, C. W.; Hoye, T. R. Macromolecules 1997, 30, 5213-5219.

A practical method for chemoselective formation of MTPA amide derivatives from amino alcohols and phenols. Hoye, T. R.; Renner, M. K.; Vos-Dinardo, T. J. J. Org. Chem. 1997, 62, 4168-4170.   

1996

Synthesis of the C2-symmetric, macrocyclic alkaloid, (+)-xestospongin A and its C(9)-epimer, (-)-xestospongin C: Impact of substrate rigidity and reaction conditions on the efficiency of the macrocyclic dimerization reaction. Hoye, T. R.; Ye, Z.; Yao, L. J.; North, J. T. J. Am. Chem. Soc. 1996, 118, 12074-12081.

Applications of MTPA (Mosher) amides of secondary amines: Assignment of absolute configuration in chiral cyclic amines. Hoye, T. R.; Renner, M. K. J. Org. Chem. 1996, 61, 8489-8495.

Studies of palladium-catalyzed cross-coupling reactions for preparation of highly hindered biaryls relevant to the korupensamine/michellamine problem. Hoye, T. R.; Chen, M. J. Org. Chem. 1996, 61, 7940-7942.

Anionic synthesis of amino and anhydride end functional polymers. Cernohous, J. J.; Macosko, C. W.; Hoye, T. R. Polymer Preprints 1996, 37(2), 653-654.

Anionic synthesis, modification, and characterization of ABC triblock copolymers. Guégan, P.; Cernohous, J. J.; Khandpur, A. K.; Hoye, T. R.; Macosko, C. W. Macromolecules 1996, 29, 4605-4612.

Total synthesis of (ent)-korupensamine D. Hoye, T. R.; Chen, M. Tetrahedron Lett. 1996, 37, 3099-3100.

Total syntheses of korupensamine C and ancistrobrevine B. Hoye, T. R.; Mi, L. Tetrahedron Lett. 1996, 37, 3097-3098.

A convenient synthesis of dimethyl (diazomethyl)phosphonate (Seyferth/Gilbert reagent). Brown, D. G.; Velthuisen, E. J.; Commerford, J. R.; Brisbois, R. G.; Hoye, T. R. J. Org. Chem. 1996, 61, 2540-2541.

MTPA (Mosher) amides of cyclic secondary amines: Conformational aspects and a useful method for assignment of amine configuration. Hoye, T. R.; Renner, M. K. J. Org. Chem. 1996, 61, 2056-2064. [Erratum J. Org. Chem. 2006, 71, 1754.]

Enzyme mediated synthesis of stereoisomerically pure a,w-diepoxides. Hoye, T. R.; Tan, L. Synlett, 1996, 615-616.

A highly efficient synthesis of the potent antitumor, C35, adjacent bis-tetrahydrofuranyl, Annonaceous acetogenin, (+)-parviflorin. Hoye, T. R.; Z. Ye J. Am. Chem. Soc. 1996, 118, 1801-1802.

Intramolecular cationic cyclizations initiated by electrocyclic cleavage of cyclopropanes. Synthesis of trienic cyclopentane derivatives. Gassman, P. G.; Tan. L.; Hoye, T. R. Tetrahedron Lett. 1996, 37, 439-442.

1995

Polycyclic cyclopropanes from reactions of alkene-containing Fischer carbene complexes and alkynes: A formal synthesis of (±)-carabrone. Hoye, T. R.; Vyvyan, J. R. J. Org. Chem. 1995, 60, 4184-4195.

Determination of relative and absolute configuration in the Annonaceous acetogenins. Ramirez, E. A.; Hoye, T. R. in Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier: New York, NY, 1995; Vol 17, Structure and Chemistry (Part D), pp 251-282.

Total synthesis of the potent antitumor, bis-tetrahydrofuranyl Annonaceous acetogenins (+)-asimicin and (+)-bullatacin. Hoye, T. R.; Tan. L. Tetrahedron Lett. 1995, 36, 1981-1984.

Tandem GC/MS: A useful tool for studying end-capping reactions of oligo(styryl)lithium anions. Brestensky, D. M.; Hoye, T. R.; Macosko, C. W. J. Polym. Sci., Part A: Polym. Chem. 1995, 33, 1957-1967.

1994

Total synthesis of michellamines A-C: Important anti-HIV agents. Hoye, T. R.; Chen, M.; Mi, L.; Priest, O. Tetrahedron Lett. 1994, 35, 8747-8750.

Stereostructural studies on the 4-hydroxylated Annonaceous acetogenins: A novel use of Mosher ester data for determining relative configuration [between C(4) and C(36)]. Hoye, T. R.; Hanson, P. R.; Hasenwinkel, L. E.; Ramirez, E. A.; Zhuang, Z. Tetrahedron Lett. 1994, 35, 8529-8532.

Stereostructural studies on the 4-hydroxylated Annonaceous acetogenins: Synthesis of model butenolides of known relative and absolute configuration involving an intriguing translactonization reaction. Hoye, T. R.; Hanson, P. R.; Hasenwinkel, L. E.; Ramirez, E. A.; Zhuang, Z. Tetrahedron Lett. 1994, 35, 8525-8528.

The relative and absolute configuration of the fumonisin B1 backbone. Hoye, T. R.; Jiménez, J. I.; Shier, W. T. J. Am. Chem. Soc. 1994, 116, 9409-9410.

Conformational considerations in 1-oxaquinolizidines related to the xestospongin/araguspongine family: Reassignment of stereostructures for araguspongines B and E. Hoye, T. R.; North. J. T.; Yao, L. J. J. Org. Chem. 1994, 59, 6904-6910.

An efficient and versatile synthesis of the butenolide subunit of 4-hydroxylated Annonaceous acetogenins. Hoye, T. R.; Humpal, P. E.; Jiménez, J. I.; Mayer, M. J.; Tan. L.; Ye, Z. Tetrahedron Lett. 1994, 35, 7517-7520.

Lithium and tetramethylammonium pentacarbonyl (1-oxidoethylidene)chromate(0) <—> acetylpenta-carbonylchromate(0) as acetyl anion equivalents for conjugate addition reactions with electron deficient alkenes. Söderberg, B. C.; York, D. C.; Hoye, T. R.; Rehberg, G. M.; Suriano, J. A. Organometallics 1994, 13, 4501-4509.

A practical guide to first-order multiplet analysis in 1H NMR spectroscopy. Hoye, T. R.; Hanson, P. R.; Vyvyan, J. R. J. Org. Chem. 1994, 59, 4096-4103.

A total synthesis of (+)-xestospongin A/(+)-araguspongine D. Hoye, T. R.; North, J. T.; Yao, L. J. J. Am. Chem. Soc. 1994, 116, 2617-2618.

Enolate and other carbon nucleophile alkylation reactions using cyclic sulfates as epoxide equivalents. Hoye, T. R.; Crawford, K. B. J. Org. Chem. 1994, 59, 520-522.

1993

Synthesis of (-)-bullatacin: The enantiomer of a potent, antitumor, 4-hydroxylated, Annonaceous acetogenin. Hoye, T. R.; Hanson P. R. Tetrahedron Lett. 1993, 34, 5043-5046.

Preparation of Fischer carbene complexes by alkylation of acylmetallates with alkyl iodides. Hoye, T. R.; Chen. K.; Vyvyan, J. R. Organometallics, 1993, 12, 2806-2809.

Cobaltoctacarbonyl mediated cyclizations of electron deficient alkynones. Hoye, T. R.; Suriano, J. A. J. Org. Chem. 1993, 58, 1659-1660.

A tungsten[W(CO)5•THF]-mediated Pauson-Khand reaction: Cyclizations of 1,6-enynes via a batch-catalytic protocol. Hoye, T. R.; Suriano, J. A. J. Am. Chem. Soc. 1993, 115, 1154-1155.

1992

Determination of absolute configuration of stereogenic carbinol centers in Annonaceous acetogenins by 1H- and 19F-NMR Mosher ester analysis. Rieser, M. J.; Hui, Y.; Rupprecht, J. K.; Kozlowski, J. F.; Wood, K. V.; McLaughlin, J. L.; Hanson, P. R.; Zhuang, Z.; Hoye, T. R. J. Am. Chem. Soc. 1992, 114, 10203-10213.

A protecting group strategy for desymmetrization. Hoye, T. R.; Witowski, N. E. J. Am. Chem. Soc. 1992, 114, 7291-7292.

Reactions of pentacarbonyl(1-methoxyethylidene)molybdenum and -tungsten with a,w-enynes: Comparison with the chromium analog and resulting mechanistic ramifications. Hoye, T. R.; Suriano, J. A. Organometallics 1992, 11, 2044-2050.

Tandem alkyne insertion and allyl sulfonium ylide rearrangement of g,d-alkynyl-a'-diazoketones. Hoye, T. R.; Dinsmore, C. J. Tetrahedron Lett. 1992, 33, 169-172.

1991

Synthesis of (+)-(15,16,19,20,23,24)-hexepi-uvaricin—a bistetrahydrofuranyl Annonaceous acetogenin analog. Hoye, T. R.; Hanson, P. R.; Kovelesky, A. C.; Ocain, T. D.; Zhuang, Z. J. Am. Chem. Soc. 1991, 113, 9369-9370.

Double (internal/external) alkyne insertion reactions of a-diazoketones. Hoye, T. R.; Dinsmore, C. J. Tetrahedron Lett. 1991, 32, 3755-3758.

Assigning the relative stereochemistry between C(2) and C(4) of the 2-acetonyl-4-alkylbutyrolactone substructures of the pertinent Annonaceous acetogenins. Hoye, T. R.; Hanson, P. R. J. Org. Chem. 1991, 56, 5092-5095.

Rhodium(II) acetate catalyzed alkyne insertion reactions of a-diazoketones: Mechanistic inferences. Hoye, T. R.; Dinsmore, C. J. J. Am. Chem. Soc. 1991, 113, 4343-4344.

1990

Reactions of Cp'(CO)2Mn=C(OMe/OLi)R with enynes, 1-hexyne, and acrylates. Hoye, T. R.; Rehberg, G. M. Organometallics 1990, 9, 3014-3015.

Thermodynamic control of stereochemistry in the synthesis of 1-oxaquinolizidine skeletal portions of xestospongin A. Hoye, T. R.; North, J. T. Tetrahedron Lett. 1990, 31, 4281-4284.

Alkyne insertion reactions of metal-carbenes derived from enynyl-a-diazoketones [R'CN2COCR2CH2C­ºC(CH2)n-2CH=CH2]. Hoye, T. R.; Dinsmore, C. J.; Johnson, D. S.; Korkowski, P. F. J. Org. Chem. 1990, 55, 4518-4520.

1-Oxyalkylidenepentacarbonylchromium anion [R(O-)C=Cr(CO)5] « acylpentacarbonyl-chromate [acyl-Cr-(CO)5] chemistry: In situ preparation and reactions with alkynes and enynes. Hoye, T. R.; Rehberg, G. M. J. Am. Chem. Soc. 1990, 112, 2841-2842.

1989

(1-Pyrrolidinoethylidene)pentacarbonyl chromium mediated conversion of enynes to bicyclic, cyclopropane-containing carbon skeletons: Donor group effects. Hoye, T. R.; Rehberg, G. M. Organometallics 1989, 8, 2070-2071.

A short, oxetane-based synthesis of (±)-sarracenin. Hoye, T. R.; Richardson, W. S. J. Org. Chem. 1989, 54, 688-693.

1988

Validation of the 1H NMR chemical shift method for determination of stereochemistry in the bistetrahydrofuranyl moiety of uvaricin-related acetogenins from Annonaceae: Rolliniastatin 1 (and asimicin). Hoye, T. R.; Zhuang, Z.-p. J. Org. Chem. 1988, 53, 5578-5580.

Fischer carbene mediated conversions of enynes to bi- and tricyclic cyclopropane-containing carbon skeletons. Korkowski, P. F.; Hoye, T. R.; Rydberg, D. B. J. Am. Chem. Soc. 1988, 110, 2676-2678.

1987

Asymmetric synthesis of achiral molecules: Meso selectivity. Hoye, T. R.; Jenkins, S. A. J. Am. Chem. Soc. 1987, 109, 6196-6198 (reviewed in inaugural issue of Chemtracts 1988, 1, 29).

On the stereochemistry of the bistetrahydrofuranyl moiety of uvaricin: Proton NMR chemical shifts can play a crucial role in structure determination. Hoye, T. R.; Suhadolnik, J. C. J. Am. Chem. Soc. 1987, 109, 4402-4403.

Preparation of 5-alkyl-2-t-butyl-1,3-dioxolanones by trimethylsilyl triflate catalyzed reactions between bis-trimethylsilyl derivatives of a-hydroxycarboxylic acids and pivaldehyde. Hoye, T. R.; Peterson, B. H.; Miller, J. D. J. Org. Chem. 1987, 52, 1351-1353.

1986

Stereocontrolled synthesis of 2,5-linked bistetrahydrofurans via the triepoxide cascade reaction. Hoye, T. R.; Suhadolnik, J. C. Tetrahedron (Symposium in Print) 1986, 42, 2855-2862.

1985

Amidoacetone enolate anions: Alkylation and Michael reaction. Hoye, T. R.; Duff, S. R.; King, R. S. Tetrahedron Lett. 1985, 26, 3433-3436.

Symmetry-assisted synthesis of triepoxide stereoisomers of (E,Z,E)-dodeca-2,6,10-triene-1,12-diol and their cascade reactions to 2,5-linked bistetrahydrofurans. Hoye, T. R.; Suhadolnik, J. C. J. Am. Chem. Soc. 1985, 107, 5312-5313.

1984

Kinetic lactonization of 4,6-dimethyl- and 2,4,6,8-tetramethyl-5-hydroxy azelaic acids: Ground-state conformational control. Hoye, T. R.; Peck, D. R.; Swanson, T. A. J. Am. Chem. Soc. 1984, 106, 2738-2739.

In Situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: 1H and 31P NMR evidence for equilibration of cis- and trans-hydroxycyclophosphamide with aldophosphamide and its hydrate in aqueous solution. Borch, R. F.; Hoye, T. R.; Swanson, T. A. J. Med. Chem. 1984, 27, 490-494.

Stereochemistry of 6-methyl Hagemann's ester and its products of conjugate addition by vinyl magnesium bromide/copper (I) iodide. Hoye, T. R.; Magee, A. S.; Rosen, R. E. J. Org. Chem. 1984, 27, 3224-3226.

1983

Preparation of d,l-megaphone intermediates. Hoye, T. R.; Kurth, M. J. Tetrahedron Lett. 1983, 24, 4769-4772.

1982

Preparation and Diels-Alder reactions of 1,1-dicarbonylalkenes. Hoye, T. R.; Caruso, A. J.; Magee, A. S. J. Org. Chem. 1982, 47, 4152-4156.

Two syntheses of d,l-aplysistatin. Hoye, T. R.; Caruso, A. J.; Dellaria, J. F., Jr.; Kurth, M. J. J. Am. Chem. Soc. 1982, 104, 6704-6709.

3,5-Hexadienoic esters: A convenient preparation. Hoye, T. R.; Magee, A. S.; Trumper, W. S. Syn Comm. 1982, 12, 183-187.

3,4,5-Trimethoxyphenyllithium. Hoye, T. R.; Kaese, P. A. Syn. Comm. 1982, 12, 49-52.

Intramolecular photochemical cycloaddition reactions of 3-(1,5-dimethylhex-4-enyl)cyclohex-2-enone: regio- and stereochemical aspects. Hoye, T. R.; Martin, S. J.; Peck, D. R. J. Org. Chem. 1982, 48, 331-337.

1981

Symmetry in synthesis. Preparation and methylation of spiro dilactones. Hoye, T. R.; Peck, D. R.; Trumper, P. K. J. Am. Chem. Soc. 1981, 103, 5618-5620.

Internal nucleophilic termination in mercuric ion initiated diene cyclizations. Hoye, T. R.; Caruso, A. J.; Kurth, M. J. J. Org. Chem. 1981, 46, 3550-3552.

Steric impedance in the 1,3-photocycloaddition reaction between cyclopentene and anisole derivatives. Hoye, T. R. Tetrahedron Lett. 1981, 22, 2523-2526.

Triphenylcarbenium and tris(p-bromophenyl)ammoniumyl ion induced lactonizations of a,w-p-methoxybenzyloxy methyl esters. Hoye, T. R.; Kurth, M. J.; Lo, V. Tetrahedron Lett. 1981, 22, 815-818.

Total synthesis of d,l-ancistrofuran: A study of cyclic ether formation. Hoye, T. R.; Caruso, A. J. J. Org. Chem. 1981, 46, 1198-1205.

1980

Regio- and stereoselectivity in the ene reaction of N-phenyl-1,2,4-triazoline-3,5-dione with a,b-unsaturated carbonyl substrates. Hoye, T. R.; Bottorff, K. J.; Caruso, A. J.; Dellaria, J. F., Jr. J. Org. Chem. 1980, 45, 4287-4292.

Preparation of b-hydroxy-a-phenylthioesters via condensation of aldehydes with a-phenylthioester enolate anions. Hoye, T. R.; Kurth, M. J. J. Org. Chem. 1980, 45, 3549-3554.

1979

Total Synthesis of d,l-aplysistatin. Hoye, T. R.; Kurth, M. J. J. Am. Chem. Soc. 1979, 101, 5065-5067.

Mercuric trifluoroacetate mediated brominative cyclizations of dienes: Total synthesis of d,l-3b-bromo-8-epicaparrapi oxide. Hoye, T. R.; Kurth, M. J. J. Org. Chem. 1979, 44, 3461-3467.

Mercuric acetate oxidation of 1-vinylcycloalkenes: Diels-Alder reactivity of resultant allylic diene acetates. Hoye, T. R.; Rother, M. J. J. Org. Chem. 1979, 44, 458-461.

1978

A 1,3-diene-2-carboxylic ester synthesis: Reaction of alkylidene-g-lactones with potassium and sodium phenyl selenoate. Hoye, T. R.; Caruso, A. J. Tetrahedron Lett. 1978, 4611-4614.

Brominative cyclizations of geranyl derivatives. Hoye, T. R.; Kurth, M. J. J. Org. Chem. 1978, 43, 3693-3697.

1977

Total synthesis of illudinine, illudalic acid, and illudacetallic acid. Woodward, R. B.; Hoye, T. R. J. Am. Chem. Soc. 1977, 99, 8007-8014.

1973

Diaziridines II. The addition of diaziridines to electrophilic acetylenes. Heine, H. W.; Hoye, T. R.; Williard, P. G.; Hoye, R. C. J. Org. Chem. 1973, 38, 2984-2988.

1972

The synthesis and reactions of some 1-(nitroaryl)diaziridines. Heine, H. W.; Williard, P. G.; Hoye, T. R. J. Org. Chem. 1972, 37, 2980-2983.