Cascade reactions of HDDA-benzynes with tethered cyclohexadienones: strain-driven events originating from ortho-annulated benzocyclobutenes
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2024-04/Get.jpeg?itok=NNX6Cq60)
Chinta, B. S.; Sneddon, D. S.; Hoye, T. R. Chem. Sci. 2024, 15, 8181–8189.
2:1 Adducts Arising from Reactions between Benzynes and 1,3,4-Oxadiazoles
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2024-04/images_large_ol4c01005_0010.jpeg?itok=mNbVrY5l)
Guzman, A. L.; Kevorkian, P. V.; Hoye, T. R. Org. Lett. 2024, 26, 3834–3839.
Deciphering molecular structures: NMR spectroscopy and quantum mechanical insights of halogenated 4H‐Chromenediones
Martins, L. M. O. S.; Souto, F. T.; Hoye, T. R.; Alvarenga, E. S. Magn. Reson. Chem. 2024, 62, 583–598.
Phosphorane-Promoted C–C Coupling during Aryne Annulations
![toc](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2024-03/anie202318774-toc-0001-m.jpg?itok=H906-zr3)
Kevorkian, P.V.; Sneddon, D.S.; Ritts, C.B.; Hoye, T.R. Angew. Chem. Int. Ed. 2024, e202318774.
Novel Conversions of a Multifunctional, Bio-sourced Lactone Carboxylic Acid
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2023-12/Screenshot%202023-12-04%20at%2011.09.27%E2%80%AFAM_0.png?itok=5Z-5rQWb)
Kaicharla, T.; Lee, S.; Wang, R.; Pehere, A. D.; Xu, S.; Hoye, T. R. Arkivoc 2024, 202312081.
Intramolecular Cyclization of Alkynylheteroaromatic Substrates Bearing a Tethered Cyano Group: A Strategy for Accessing Fused Pyridoheterocycles
![DOI](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2023-08/images_large_jo3c01411_0007.jpeg?itok=5awfBUFb)
Kraemer, N.; Eason, E. M.; Hoye, T. R. J. Org. Chem. 2023, 88, 12716–12726.
Covalent Adduct Formation between β-Lactoglobulin and Flavor Compounds under Thermal Treatments That Mimic Food Pasteurization or Sterilization
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2023-06/images_large_jf3c01220_0009.jpeg?itok=FMDdVgok)
Yuan, J.; Anantharamkrishnan, V.; Hoye, T. R.; Reineccius, G. A. J. Agric. Food Chem. 2023, 71, 9481–9489.
Neighboring Group Effects on the Rates of Cleavage of Si–O–Si-Containing Compounds
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2023-02/images_large_jo2c02126_0011.jpeg?itok=suZIGYFK)
Gormong, E. A.; Sneddon, D. S.; Reineke, T. M.; Hoye, T. R. J. Org. Chem. 2023, 88, 1988–1995.
The Dual Therapeutic Potential of Ottelione A on Carbon Tetrachloride-induced Hepatic Toxicity in Mice
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2023-02/12010_2023_4346_Figa_HTML.jpeg?itok=gx9wK8zG)
Zahran, R. F.; EL-sayed, L. M.; Hoye, T. R.; Ayyad, S-E. N. Appl. Biochem. Biotechnol. 2023, 195, 5966–5979.
Examples Showing the Utility of Doping Experiments in 1H NMR Analysis of Mixtures
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/images_large_jo1c03127_0007.jpeg?itok=3HjL5gC3)
Kaicharla, T.; Chinta, B.S.; Hoye, T.R. J. Org. Chem. 2022, 87, 5660–5667.
In Situ Allene Formation via Alkyne Tautomerization to Promote [4 + 2]-Cycloadditions with a Pendant Alkyne or Nitrile
![TOC](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/acs.orglett.2c00491.gif?itok=v29jObkt)
Kraemer, N.; Naredla, R.R.; Hoye, T.R. Org. Lett. 2022, 24, 2327–2331.
Defining the Macromolecules of Tomorrow through Synergistic Sustainable Polymer Research
![cr1c00173_0074](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/cr1c00173_0074.gif?itok=7HxmO02g)
Haque, F.M.; Ishibashi, J.S.A.; Lidston, C.A.L.; Shao, H.; Bates, F.S.; Chang, A.B.; Coates, G.W.; Cramer, C.J.; Dauenhauer, P.J.; Dichtel, W.R.; Ellison, C.J.; Gormong, E.A.; Hamachi, L.S.; Hoye, T.R.; Jin, M.; Kalow, J.A.; Kim, H.J.; Kumar, G.; LaSalle, C.J.; Liffland, S.; Lipinski, B.M.; Pang, Y.; Parveen, R.; Peng, X.; Popowski, Y.; Prebihalo, E.A.; Reddi, Y.; Reineke, T.M.; Sheppard, D.T.; Swartz, J.L.; Tolman, W.B.; Vlaisavljevich, B.; Wissinger, J.; Xu, S.; Hillmyer, M.A. Chem. Rev. 2022, 122, 6322–6373.
Hydrothermal catalysis of waste greases into green gasoline, jet, and diesel biofuels in continuous flow supercritical water
Fedie, R.L.; McNeff, C.V.; McNeff, C.V.; McNeff, L.C.; Greuel, P.G.; Yan, B.; Jenkins, J.A.; Brethorst, J.T.; Frost, G.B.; Hoye, T.R. Biofuels, Bioprod. Bioref. 2022, 16, 349–369.
Synthesis of a novel naphthalenone endoperoxide and structural elucidation by NMR spectroscopy and theoretical calculation
Martins, L.M.O.S.; Santos, J.O.; Hoye, T.R.; Alvarenga, E.S. Magn. Reson. Chem. 2022, 60, 139–147.
Sulfurane [S(IV)]-Mediated Fusion of Benzynes Leads to Helical Dibenzofurans
![abstract graphic](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/abstract_graphic.png?itok=sFEuRuzL)
Ritts, C.B.; Hoye, T.R. J. Am. Chem. Soc. 2021, 143, 13501–13506.
Highlighted in JACS Spotlights 2021, 143, 16875–16876. (DOI: 10.1021/jacs.1c10754)
and in Synfacts 2021, 17, 1213. (DOI: 10.1055/s-0040-1720748)
Synthesis of Isohexide Diyne Polymers and Hydrogenation to Their Saturated Polyethers
![Synthesis of Isohexide Diyne Polymers and Hydrogenation to Their Saturated Polyethers](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/mz1c00422_0006.gif?itok=C_gzV5A9)
Gormong, E.A.; Reineke, T.M.; Hoye, T.R. ACS Macro Lett. 2021, 10, 1068–1072.
Hexadehydro Diels–Alder (HDDA) Route to Arynes and Related Chemistry
Voss, R.N.; Hoye, T.R. Hexadehydro Diels–Alder (HDDA) Route to Arynes and Related Chemistry. In Modern Aryne Chemistry; Biju, A.T.; Wiley-VCH: Weinheim, Germany, 2021; Chapter 10; pp 407–444.
β-Methyl-δ-valerolactone-containing thermoplastic poly(ester-amide)s: synthesis, mechanical properties, and degradation behavior
![pc](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/capture.jpg?itok=IeHaxWaG)
Guptill, D. M.; Chinta, B. S.; Kaicharla, T.; Xu, S.; Hoye, T. R. Polym. Chem. 2021, 12, 1310–1316.
Characterization of stereoisomeric 5‐(2‐nitro‐1‐phenylethyl)furan‐2(5H )‐ones by computation of 1H and 13C NMR chemical shifts and electronic circular dichroism spectra
![toc](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2022-12/mrc5073-toc-0001-m.jpg?itok=kjPzc8yL)
Lopes, D. T.; Hoye, T. R.; Alvarenga, E. S. Magn. Reson. Chem. 2021, 59, 43–51.
Poly(4-ketovalerolactone) from Levulinic Acid: Synthesis and Hydrolytic Degradation
![sxu](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/toc_ma0c00787_0009.gif?itok=K30yheMA)
Xu, S.; Wang, Y.; Hoye, T. R. Macromolecules 2020, 53, 4952–4959.
Covalent Adduct Formation Between Flavor Compounds of Various Functional Group Classes and the Model Protein β-Lactoglobulin
![ja](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/jf0c01925_0010.gif?itok=tr3rn_sb)
Anantharamkrishnan, V.; Hoye, T. R.; Reineccius, G. A. J. Agric. Food Chem. 2020, 68, 6395–6402.
4-Carboalkoxylated Polyvalerolactones from Malic Acid: Tough and Degradable Polyesters
![gf](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ma0c00212_0012.gif?itok=JwIcUi7s)
Fahnhorst, G. W.; De Hoe, G. X.; Hillmyer, M. A.; Hoye, T. R. Macromolecules 2020, 53, 3194–3201.
Reactions of HDDA Benzynes with C,N-Diarylimines (ArCH=NAr′)
![ejoc toc](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/2022-12/ejoc201901855-toc-0001-m.jpg?itok=KxNq9v4J)
Arora, S.; Sneddon, D. S.; Hoye, T. R. Eur. J. Org. Chem. 2020, 2379–2383.
Addendum: A guide to small-molecule structure assignment through computation of (¹H and ¹³C) NMR chemical shifts
Willoughby, P.H.; Jansma, M.J.; Hoye, T.R. Nat. Protoc. 2020, 15, 2777.
The aza-hexadehydro-Diels-Alder (aza-HDDA) reaction
![skt](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ja9b11243_0005.jpeg?itok=gLnO5TK8)
Thompson, S. K.; Hoye, T. R. J. Am. Chem. Soc. 2019, 141, 19575–19580.
Reactions of thermally generated benzynes with six-membered N–heteroaromatics: Pathway and product diversity
![sa](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/sahil.png?itok=77-XVNfL)
Arora, S.; Zhang, J.; Pogula, V.; Hoye, T. R. Chem. Sci. 2019, 10, 9069–9076.
Hydrolytically-degradable homo- and copolymers of a strained exocyclic hemiacetal ester
![get](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/get.png?itok=Z71fq15s)
Neitzel, A. E.; Barreda, L.; Trotta, J. T.; Fahnhorst, G. W.; Haversang, T. J.; Hoye, T. R.; Fors, B. P.; Hillmyer, M. A. Polym. Chem. 2019, 10, 4573–4583.
Superabsorbent Poly(isoprenecarboxylate) Hydrogels from Glucose
![gwff](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/sc-2019-00218g_0005.gif?itok=2rgHTRXi)
Fahnhorst, G. W.; Hoye, T. R. ACS Sustainable Chem. Eng. 2019, 7, 7491–7495.
Reactions of Diaziridines with Benzynes Give N‑Arylhydrazones
![sahil](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2018-034392_0007.gif?itok=RL-c-9Zm)
Arora, S.; Palani, V.; Hoye, T. R. Org. Lett. 2018, 20, 8082–8085.
This manuscript is dedicated in memory of Professor Harold W. Heine, formerly of Bucknell University, and in recognition of his considerable scientific and mentoring legacy, which has so positively impacted so many (including the outgoing Editor-in-Chief of Organic Letters).
Cu(I)-Mediated Bromoalkynylation and Hydroalkynylation Reactions of Unsymmetrical Benzynes: Complementary Modes of Addition
![acie](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/toc_acie.gif?itok=z9-5ICku)
Xiao, X.; Wang, T.; Xu, F.; Hoye, T. R. Angew. Chem. Int. Ed. 2018, 57, 16564–16568.
BF3-Promoted, Carbene-like, C–H Insertion Reactions of Benzynes
![jacs](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ja-2018-102068_0006.gif?itok=K5tTrG4m)
Shen, H.; Xiao, X.; Haj, M. K.; Willoughby, P. H.; Hoye, T. R. J. Am. Chem. Soc. 2018, 140, 15616–15620.
Isomerization of Linear to Hyperbranched Polymers: Two Isomeric Lactones Converge via Metastable Isostructural Polyesters to a Highly Branched Analogue
![gwf tolman](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/mz-2018-006212_0005.gif?itok=TXXGAwGd)
Fahnhorst, G. W.; Stasiw, D. E.; Tolman, W. B.; Hoye, T. R. ACS Macro Lett. 2018, 7, 1144–1148.
Atypical Mode of [3 + 2]-Cycloaddition: Pseudo-1,3-dipole Behavior in Reactions of Electron-Deficient Thioamides with Benzynes
![JT oL](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2018-02133v_0007.gif?itok=coEmmP4_)
Zhang, J.; Page, A. C. S.; Palani, V.; Chen, J.; Hoye, T. R. Org. Lett. 2018, 20, 5550–5553.
Fatty-acid derivative acts as a sea lamprey migratory pheromone
![f2](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/f2.medium.gif?itok=6YEE0ASQ)
Li, K.; Brant, C. O.; Huertas, M.; Hessler, E. J.; Mezei, G.; Scott, A. M.; Hoye, T. R.; Li, W. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 8603–8608.
Unraveling substituent effects on the glass transition temperatures of biorenewable polyesters
![nat commun](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/nat_commun.jpg?itok=oKgHLGNp)
Yu, X.; Jia, J.; Xu, S.; Lao, K. U.; Sanford, M. J.; Ramakrishnan, R. K.; Nazarenko, S. I.; Hoye, T. R.; Coates, G. W.; DiStasio R. A. Jr. Nature Commun. 2018, 9, 2880.
The domino hexadehydro-Diels–Alder reaction transforms polyynes to benzynes to naphthynes to anthracynes to tetracynes (and beyond?)
![domino](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/dominohdda.png?itok=iLkBt4bO)
Xiao, X.; Hoye, T. R. Nature Chem. 2018, 10, 838–844.
Highlighted in Synfacts 2018, 14, 1035. (DOI: 10.1055/s-0037-1610940)
and in Chem 2018, 4, 2272–2274. (DOI: 10.1016/j.chempr.2018.09.021)
Benzocyclobutadienes: An unusual mode of access reveals unusual modes of reactivity
![acie](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/capture_0.png?itok=EKr9Q1fj)
Xiao, X.; Woods, B. P.; Xiu, W.; Hoye, T. R. Angew. Chem. Int. Ed. 2018, 57, 9901–9905.
Engineering the Production of Dipicolinic Acid in E. coli
![gwf kc zhang](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/gwf.png?itok=kFMrFUTs)
McClintock, M. K.; Fahnhorst, G. W.; Hoye, T. R.; Zhang, K. Metab. Eng. 2018, 48, 208–217.
Trapping of Hexadehydro-Diels–Alder Benzynes with Exocyclic, Conjugated Enals as a Route to Fused Spirocyclic Benzopyran Motifs
![syn lett 2017](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/capture.png?itok=Q1-pU_gC)
Wang, T.; Oswood, C. J.; Hoye, T. R. Syn. Lett. 2017, 28, A-C.
Dedicated with very best wishes to Professor Victor Snieckus on the occasion of his 80th birthday.
Bile Salt-like Dienones Having a Novel Skeleton or a Rare Substitution Pattern Function as Chemical Cues in Adult Sea Lamprey
![ol-2017](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2017-01921y_0006.gif?itok=bfJkawkl)
Li, K.; Scott, A.M.; Brant, C.O.; Fissette, S.D.; Riedy, J.J.; Hoye, T.R.; Li, W. Org. Lett. 2017, 19, 4444–4447.
The Photochemical Hexadehydro-Diels-Alder (hv-HDDA) Reaction
![photochemical hdda](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/hvhdda.png?itok=2ZifKIs_)
Xu, F.; Xiao, X.; Hoye, T. R. J. Am. Chem. Soc. 2017, 139, 8400–8403.
Highlighted in Synfacts 2017, 13, 809. (DOI: 10.1055/s-0036-1590716)
Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment
![2017003](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/13659_2017_125_figa_html.gif?itok=JQZ3b3Yc)
Nyongbela, K.D.; Ntie-Kang, F.; Hoye, T.R.; Efange, S.M.N. Nat. Prod. Bioprospect. 2017, 1–13.
Thermoplastic polyurethanes from b-methyl-d-valerolactone-derived amidodiol chain extenders
![2017001](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/20170011-s2.0-s0032386117300599-fx1_1.jpg?itok=4qRj2WNp)
Guptill, D. M.; Brutman, J. P.; Hoye, T. R. Polymer 2017, 111, 252–257.
The phenol-ene reaction: Biaryl synthesis via trapping reactions between HDDA-generated benzynes and phenolics
![The Phenol–Ene Reaction: Biaryl Synthesis via Trapping Reactions between HDDA-Generated Benzynes and Phenolics](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2016-02830x_0008.gif?itok=zq1y1Qzf)
Zhang, J.; Niu, D.; Brinker, V. A.; Hoye, T. R. Org. Lett. 2016, 18, 5596–5599.
Poly(isoprenecarboxylates) from glucose via anhydromevalonolactone
![acs macro ball-jones](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/mz-2016-00560s_0007.gif?itok=BpaLYOgN)
Ball-Jones, N. R.; Fahnhorst, G. W.; Hoye, T. R. ACS Macro Lett. 2016, 5, 1128–1131.
Blue-emitting arylalkynyl naphthalene derivatives via a hexadehydro-Diels-Alder (HDDA) cascade reaction
![jacs xu 2016](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ja-2016-07647j_0007.gif?itok=IbJit6kI)
Xu, F.; Hershey, K. W.; Holmes, R. J.; Hoye, T. R. J. Am. Chem. Soc. 2016, 138, 12739–12742.
The hexadehydro-Diels–Alder (HDDA) cycloisomerization reaction proceeds by a stepwise mechanism
![jacs tao 2016](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ja-2016-037866_0008.gif?itok=jmpRB6AR)
Wang, T.; Niu, D.; Hoye, T. R. J. Am. Chem. Soc. 2016, 138, 7832–7835.
Diels-Alder reactions of furans with itaconic anhydride: Overcoming unfavorable thermodynamics
![ol pehere 2016](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2016-009292_0006.gif?itok=BnShq6cR)
Pehere, A. D.; Xu, S.; Thompson, S. K.; Hillmyer, M. A.; Hoye, T. R. Org. Lett. 2016, 18, 2584–2587.
The pentadehydro-Diels–Alder reaction
![nature wang 2016](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/graphicsforpdda.png?itok=op5cQJth)
Wang, T.; Naredla, R. R.; Thompson, S. K.; Hoye, T. R. Nature 2016, 532, 484–488.
Reactions of HDDA-derived benzynes with sulfides: Mechanism, modes, and three-component reactions
![jacs chen 2016](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ja-2016-010254_0006.gif?itok=aHuSqYbc)
Chen, J.; Palani, V.; Hoye, T. R. J. Am. Chem. Soc. 2016, 138, 4318–4321.
Isolation and characterization of sclerienone C from Scleria striatinux
![kennedy](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/graphabsforkdn.png?itok=L3pWaeJw)
Nyongbela, K. D.; Makolo, F. L.; Hoye, T. R.; Efange, S. M. Nat. Prod. Commun. 2016, 11, 5–6.
Nanoparticles containing high loads of paclitaxel silicate prodrugs: Formulation, drug release, and anti-cancer efficacy
![michel 2015](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/mp-2015-005302_0006.gif?itok=GVtgjHBf)
Han, J.; Michel, A. R.; Lee, H. S.; Kalscheuer, S.; Wohl, A.; Hoye, T. R.; McCormick, A. V.; Panyam, J.; Macosko, C. W. Mol. Pharmaceutics 2015, 12, 4329–4335.
Mechanism of the intramolecular hexadehydro-Diels–Alder reaction
![joc woods 2015](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/jo-2015-01356w_0009.gif?itok=vRYB-93M)
Marell, D. J.; Furan, L. R.; Woods, B. P.; Lei, X.; Bendelsmith, A. J.; Cramer, C. J.; Hoye, T. R.; Kuwata, K. T. J. Org. Chem. 2015, 80, 11744–11754.
Invited contribution to special issue: 50 Years and Counting: The Woodward-Hoffmann Rules in the 21st Century
Competition between classical and hexadehydro-Diels–Alder (HDDA) reactions of HDDA triynes with furan
![tet lett 2015 quang](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/1-s2.0-s0040403914021078-fx1.jpg?itok=1Q7ELSdC)
Luu Nguyen, Q.; Baire, B.; Hoye, T. R. Tetrahedron Lett. 2015, 56, 3265–3267.
We dedicate this Letter to the memory of Harry H. Wasserman, whose amalgamation of scholarship, artistry, and humanity stand as an admirable model for all to emulate.
iso-Petromyroxols: Novel dihydroxylated tetrahydrofuran enantiomers from sea lamprey (Petromyzon marinus)
![molecule 2015](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2015_iso-petromyroxol_website_abstract.png?itok=M9y3u2QR)
Li, K.; Brant, C.; Bussy, U.; Pinnamaneni, H.; Patel, H.; Hoye, T. R.; Li, W. Molecules 2015, 20, 5215–5222.
Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin
Ayyad, S.E.N.; Hoye, T. R.; Alarif, W. M.; Al Ahmadi, S. M.; Basaif, S. A.; Ghandourah, M. A.; Badria, F. A. Zeitschrift für Naturforschung C. 2015, 70, 87–92.
New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge
![2015](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2015_petromyroxols_ol_website_abstract.png?itok=Kd0vZUD2)
Hoye, T. R.; Alarif, W. M.; Basaif, S. S.; Abo-Elkarm, M.; Hamann, M. T.; Wahba, A. E.; Ayyad, S. N. ARKIVOC 2015, 164–175.
(+)- and (-)-Petromyroxols: Antipodal tetrahydrofurandiols from larval sea lamprey (Petromyzon marinus l.) that elicit enantioselective olfactory responses
![ol li 2015](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2014-033893_0006.gif?itok=6n7w91q1)
Li, K.; Huertas, M.; Brant, C.; Chung-Davidson, Y-W.; Bussy, U.; Hoye, T. R.; Li, W. Org. Lett. 2015, 17, 286–289.
Mechanism of the reactions of alcohols with o-benzynes
![jacs willo 2014](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ja-2014-02595m_0011.gif?itok=3tkkpeve)
Willoughby, P. H.; Niu, D.; Wang, T.; Haj, M. K.; Cramer, C. J.; Hoye, T. R. J. Am. Chem. Soc. 2014, 136, 13657–13665.
Ultra-high-throughput screening of natural product extracts to identify proapoptotic inhibitors of Bcl-2 family proteins
![2014 hassig j biomol screen](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2014_hassig_hts_j_biomol_screen.jpg?itok=wrSWJPBJ)
Hassig, C.A.; Zeng, F.Y.; Kung, P.; Kiankarimi, M.; Kim, S.; Diaz, P.W.; Zhai, D.; Welsh, K.; Morshedian, S.; Su, Y.; O’Keefe, B.; Newman, D.J.; Rusman, Y.; Kaur, H.; Salomon, C.E.; Brown, S.G.; Baire, B.; Michel, A. R.; Hoye, T. R.; Francis, S.; Georg, G.I.; Walters, M.A.; Divlianska, D.B.; Roth, G.P.; Wright, A.E.; Reed, J.C. J. Biomol. Screen. 2014, 19, 1201–1211.
Rates of hexadehydro-Diels–Alder (HDDA) cyclizations: Impact of the linker structure
![ol woods 2014 2](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2014-02131r_0008.gif?itok=Lv7US1dK)
Woods, B. P.; Baire, B. ; Hoye, T. R. Org. Lett. 2014, 16, 4578–4581.
Sustainable thermoplastic elastomers from terpene-derived monomers
![macro bolton 2014](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/mz-2014-00339h_0007.gif?itok=kree5LUR)
Bolton, J. M.; Hillmyer, M. A.; Hoye, T. R. ACS Macro Lett. 2014, 3, 717–720.
Silicate esters of paclitaxel and docetaxel: synthesis, hydrophobicity, hydrolytic stability, cytotoxicity, and prodrug potential
![jmc wohl 2014](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/jm-2013-01708f_0004.gif?itok=esU716Al)
Wohl, A. R.; Michel, A. R.; Kalscheuer, S.; Macosko, C. W.; Panyam, J.; Hoye, T. R. J. Med. Chem. 2014, 57, 2368–2379.
A guide to small-molecule structure assignment through computation of (1H and 13C) NMR chemical shifts
![2014 nat protocol](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2014_nmr_nature_protocols_website_abstract.png?itok=uFbWq4H6)
Willoughby, P. H.; Jansma, M. J.; Hoye, T. R. Nat. Protoc. 2014, 9, 643–660.
Addendum: Nat. Protoc. 2020, 15, 2277. (DOI: 10.1038/s41596-020-0293-9)
Analysis of seven-membered lactones by computational NMR methods: Proton NMR chemical shift data are more discriminating than carbon
![joc marell 2014](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/jo-2013-02627s_0010.gif?itok=2ppy_Hyy)
Marell, D. J.; Emond, S. J.; Kulshrestha, A.; Hoye, T. R. J. Org. Chem. 2014, 79, 753–758.
Dichlorination of (HDDA-generated) benzynes and a protocol for interrogating the kinetic order of bimolecular aryne trapping reactions
![ol niu 2014](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2013-03258c_0007.gif?itok=Sm3azHmA)
Niu, D.; Wang, T.; Woods, B. P.; Hoye, T. R. Org. Lett. 2014, 16, 254–257.
The aromatic ene reaction
![nat chem 2014 niu](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2014_aromatic_ene_website_abstract.png?itok=P5KOf1tG)
Niu, D.; Hoye, T. R. Nature Chem. 2014, 6, 34–40.
Highlighted in Synfacts 2014, 10, 258. (DOI: 10.1055/s-0033-1340776)
Flash nanoprecipitation: particle structure and stability
![2013 mp](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/mp-2013-00337f_0012.gif?itok=QnapxiPs)
Pustulka, K. M.; Wohl, A. R.; Lee, H. S.; Michel, A. R.; Han, J.; Hoye, T. R.; McCormick, A. V.; Panyam, J.; Macosko, C. W. Mol. Pharmaceutics 2013, 10, 4367–4377.
Alkane desaturation by concerted double hydrogen atom transfer to benzyne
![2013 nature](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2013_h2-transfer_nautre_eileen_website_abstract.png?itok=Z2AaBPHv)
Niu, D.; Willoughby, P. H.; Baire, B.; Woods, B. P.; Hoye, T. R. Nature 2013, 501, 531–534.
Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group
![2013 cs](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2013_cs.gif?itok=zB2o9UXT)
Izgu, E. C.; Hoye, T. R. Chem. Sci. 2013, 4, 2262–2266
Highlighted in Synfacts 2013, 9, 589. (DOI: 10.1005/s-0033-1338715)
New diarylheptanoids and a hydroxylated ottelione from Ottelia alismoides
![2013004](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2013004.png?itok=o15-vOCw)
Hoye, T. R.; Ayyad, S. E. N.; Beckord, H. J.; Brown, S. G. Natural Prod. Commun. 2013, 8, 351–358.
Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer
![2013003](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2013003.png?itok=Ph69Nl8D)
Dings, R. P. M.; Levine J. I.; Brown, S. G.; Astorgues-Xerri, L.; MacDonald, J. R.; Hoye, T. .R.; Raymond, E.; Mayo, K. H. Invest. New Drugs 2013, 31, 1142–1150.
Synthesis of complex benzenoids via the intermediate generation of o-benzynes through the hexadehydro-Diels-Alder reaction
![2013 nat protocol](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2013_hdda_nature_protocols_website_abstract.png?itok=J9VmT7Sh)
Baire, B.; Niu, D.; Willoughby, P. H.; Woods, B. P.; Hoye, T. R. Nat. Protoc. 2013, 8, 501–508.
Structure-based optimization of angiostatic agent 6DBF7, an allosteric antagonist of galectin-1
![2013001](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2013001.png?itok=Es_zJ3iW)
Dings, R. P. M.; Kumar, N.; Miller, M. C.; Loren, M. L.; Rangwala, H.; Hoye, T. R.; Mayo, K. H. J. Pharm. Exp. Ther. 2013, 344, 589–599.
The hexadehydro-Diels–Alder reaction
![2012 hdda nature](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2012_hdda_nature_website_abstract.png?itok=GrpAinFZ)
Hoye, T. R.; Baire, B.; Niu, D.; Willoughby, P. H.; Woods, B. P. Nature 2012, 490, 208–212.
Highlighted in Synfacts 2013, 9, 153. (DOI: 10.1005/s-0033-1318087)
Polyurethanes based on renewable polyols from bioderived lactones
![2012007](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2012_pc.gif?itok=-wZZBWaF)
Gurusamy-Thangavelu, S. A.; Emond, S. J.; Kulshrestha, A.; Hillmyer, M. A.; Macosko, C. W.; Tolman, W. B.; Hoye, T. R. Polymer Chemistry 2012, 3, 2941–2948.
Effects of block copolymer properties on nanocarrier protection from in vivo clearance
![2012006](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/1-s2.0-s0168365912005202-fx1.jpg?itok=GPCwNJOV)
D'Addio, S. M.; Saad, W.; Ansell, S. M.; Squiers, J. J.; Adamson, D. H.; Herrera-Alonso, M.; Wohl, A. R.; Hoye, T. R.; Macosko, C. W.; Mayer, L. D.; Vauthier, C.; Prud'homme, R. K. J. Control. Release 2012, 162, 208–217.
A simple confined impingement jets mixer for flash nanoprecipitation
![2012004](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/2012_cij_mixer_website_graphic.png?itok=hpvwUboO)
Han, J.; Zhu, Z.; Qian, H.; Wohl, A. R.; Beaman, C. J.; Hoye, T. R.; Macosko, C. W. J. Pharm. Sci. 2012, 101, 4018–4023.
Case study of empirical and computational chemical shift analyses: Reassignment of the relative configuration of phomopsichalasin to that of diaporthichalasin
![2012 jnp](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/np-2012-00248w_0006.gif?itok=SF6YuOzq)
Brown, S. G.; Jansma, M. J.; Hoye, T. R. J. Nat. Prod. 2012, 75, 1326–1331.
Anti-tumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding
![2012 jmc](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/jm-2012-00014q_0001.gif?itok=AhGfbKxF)
Dings, R. P. M.; Miller, M.; Nesmelova, I. V.; Astorgues-Xerri, L.; Kumar, N.; Serova, M.; Chen, X.; Raymond, E.; Hoye, T. R.; Mayo, K. H. J. Med. Chem. 2012, 55, 5121-5129.
A concise total synthesis of (±)- and (–)-okilactomycin D
![2012 ol niu](/sites/hoye.chem.umn.edu/files/styles/folwell_half/public/files/ol-2011-03355g_0006.gif?itok=8hpa8rBe)
Niu, D.; Hoye, T. R. Org. Lett. 2012, 14, 828–831.
Highlighted in the following editorial: Terpenoid- and shikimate-derived natural product total synthesis: A personal analysis and commentary on the importance of the papers that appear in this virtual issue. Hale, K. J. Org. Lett. 2013, 15, 3181–3198.